Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease
نویسندگان
چکیده
منابع مشابه
Mechanisms of HIV-associated lymphocyte apoptosis.
Infection with the human immunodeficiency virus (HIV) is associated with a progressive decrease in CD4 T-cell number and a consequent impairment in host immune defenses. Analysis of T cells from patients infected with HIV, or of T cells infected in vitro with HIV, demonstrates a significant fraction of both infected and uninfected cells dying by apoptosis. The many mechanisms that contribute to...
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Aberrant expression of regulatory receptors programmed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhaustion of T lymphocytes during chronic human immunodeficiency virus type 1 (HIV-1) infection; however, less is known about whether a similar process impacts B-lymphocyte function during HIV-1 infection. We reasoned that disruption of the peripheral...
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Progression from infection with the Human Immunodeficiency Virus (HIV) to AIDS is a complex process that remains poorly understood. While mathematical models representing the ongoing battle between HIV and the immune system have been successful, they remain focused on cellular, as opposed to humoral, immunity. This situation remains in spite of the fact that recent evidence has shown the mediat...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2008
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2008.04.034